中国临床药理学杂志Issue(23)：2300-2302,3.DOI:10.13699/j.cnki.1001-6821.2015.23.007
七氟烷后处理对肝癌根治术患者肝缺血再灌注损伤的影响
Effect of sevoflurane postconditioning on hepatic ischemia reperfusion injury in patients with radical resection of liver cancer
摘要
Abstract
Objective To evaluate the effect of sevoflurane postcondi-tioning on hepatic ischemia reperfusion injury in patients with ra-dical re-section of liver cancer.Methods Sixty patients undergoing elective ra-dical resection of liver cancer were randomly divided into control group (30 cases) and treatment group(30 cases).Patients in control group were given propofol 8 mg・ kg -1・ h-1 +remifentanil 1 μg・ kg-1・ h -1 and cisatracurium 1 μg・ kg -1・ h-1 .Patients in treatment group were given the same methods with control group, and inhaled 2% sevoflurane for 30 min after disparking the blood stream of hepatic hilum, and clean them for 15 min.10 mL of venous blood was collected at the each time point:the time of pre-operation ( T0 ) , the end of operation ( T1 ) , post operation 1 d ( T2 ) , 3 d ( T3 ) , 5 d ( T4 ) and 7 d ( T5 ).The serum ala-nine aminotransferase ( ALT ) , aspartate aminotransferase ( AST ) , ma-londialdehyde ( MDA ) , superoxide dismutase ( SOD ) , tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1) and interleukin-10 (IL-10) in the different time point between two groups were compared.And the hospitalization time between two groups was also compared.Results AST, MDA, SOD, TNF-αand IL-1 were higher than T0 in each group after operation (P<0.05).ALT, AST and MDA of treat-ment group were significantly lower than those of control group in the T2、T3、T4 and T5 ( P<0.05).TNF-αand IL-1 of treatment group were significantly lower than those of control group in the T2 , T3 and T4 ( P <0.05 ) .SOD and IL-10 of treatment group were significantly higher than those of control group in the T2, T3, T4 and T5(P<0.05). The length of stay in hospital of treatment group was significantly shorter than that of control group ( P <0.05 ) . Conclusion Sevoflurane postconditioning can alleviate hepatic ischemia reperfusion injury on patients under radical resection of liver cancer through the decrease of the activation and release of TNF-α, and IL-1, the suppression and elimination of oxygen free radicals, and the acceleration of the activation and release of IL-10.关键词
七氟烷/后处理/肝癌根治术/缺血再灌注损伤Key words
sevoflurane/postconditioning/radical resection of liver cancer/hepatic ischemia reperfusion injury分类
医药卫生引用本文复制引用
胡礼宏,徐霞,董永平,韩新生,陆才德..七氟烷后处理对肝癌根治术患者肝缺血再灌注损伤的影响[J].中国临床药理学杂志,2015,(23):2300-2302,3.基金项目
浙江省医学会临床科研基金资金项目（2011ZYC －A52）；宁波市卫生局医学科技计划基金资助项目 （）
