中国临床药理学杂志2016，Vol.32Issue(1)：3-5,3.DOI:10.13699/j.cnki.1001-6821.2016.01.001
糖皮质激素对哮喘患儿的临床疗效及作用机制研究
Clinical efficacy of inhaled corticosteroids on asthma in children and its mechanism
摘要
Abstract
Objective To investigate the clinical efficacy of inhaled stereoscopic on asthma in children and its mechanism .Methods Ninety children with asthma were divided into treatment group and the control group, 45 cases in each group.The control group received conventional treatment , and treatment group received inhaled corticosteroid therapy on the basis of conventional therapy , children under 5 years old were given fluticasone propionate inhalation aerosol spray treatment , 100.0-250.0μg· d-1 , 2 times a day; children older than 5 years were given budes-onide inhalation therapy , 200.0-400.0 μg· d-1 , 2 times a day.Treat-ment lasted for four weeks , the clinical efficacy , serum neurotrophin -3 ( NT-3) , and the changes of peripheral blood eosinophils ( EOS) of two groups were observed .Results The total effective rate was 95.56% in treatment group , significantly higher than that in control group , which was 71.11%.After treatment , the levels of NT-3 and EOS of two groups were significantly reduced than those before treatment , but treatment group decreased more than control group (P<0.05).Conclusion Taking inhaled stereoscopic in the treatment process of pediatric asthma can improve clinical outcomes.Its mechanism of action might be that it reduced the serum neuro-transmitter -3 and peripheral blood anglophile count , controlled airway inflammation, and thereby, further improved the clinical efficacy.关键词
小儿哮喘/吸入型/糖皮质激素/神经营养素-3/嗜酸性粒细胞Key words
children with asthma/inhaled/contortionists/neurotransmitter-3/oenophiles分类
医药卫生引用本文复制引用
彭芬,黄华,钱炜..糖皮质激素对哮喘患儿的临床疗效及作用机制研究[J].中国临床药理学杂志,2016,32(1):3-5,3.基金项目
2011年江苏省六大人才高峰项目基金资助项目(2011021) （2011021）
