中国临床药理学杂志2016，Vol.32Issue(1)：15-17,3.DOI:10.13699/j.cnki.1001-6821.2016.01.005
贝前列素钠联用氯沙坦钾对糖尿病肾病早期患者的临床研究
Clinical study of beraprost sodium and losartan potassium in patients with early diabetic nephropatly
摘要
Abstract
Objective To evaluate the effects of beraprost sodium com-bined with losartan potassium on kidney function and microalbuminuria index of patients with early diabetic nephropathy .Methods A total of 68 cases of patients with early diabetic nephropathy were divided into the trial group ( n=34 ) and control group ( n=34 ) .The patients of control group were treated with conventional symptomatic treatment and beraprost sodium 40 μg, tid.On the basis of control group , the patients of trial group were treated with losartan potassium 50 mg, qd.The treatment for patients of two groups all lasted for 12 weeks.The changes in renal func-tion ( serum creatinine , blood urea nitrogen , homocysteine , cystatin C levels ) , and microalbuminuria index (β2 microglobulin , urine mi-croalbumin , urinary microalbumin /urine creatinine , 24 h urinary albu-min excretion rate ) and blood pressure , blood glucose and glycosylated hemoglobin of the two groups before and after the treatment were ob-served.Results In the terms of urea nitrogen , homocysteine , cystatin C,β2 microglobulin, urine microalbumin, urinary microalbumin /urine creatinine , 24 h urinary albumin excretion rate , the patients of twogroups all significantly decreased than before treatment (P <0.05), and in the terms of homocysteine , cystatin C, mi-croalbuminuria index , the patients of the trial group got more significant decline ( P <0.05 ) , but in the terms of serum creatinine, urea nitrogen, there was no significant difference between the two groups (P>0.05).The blood pressure of two groups significantly decreased after treatment , but blood glucose and glycosylated hemoglobin of two groups all got no significant difference than those of before treatment ( P>0.05 ) .There was no serious adverse drug reactions in the two groups, including coughing , elevated serum potassium and so on .Conclusion The beraprost sodium com-bined with losartan potassium can protect the kidney endothelial cells and improve kidney function of patients with early diabetic nephropathy , effectively reduce urinary protein and slow the progression of disease with high safety .关键词
糖尿病肾病/贝前列素钠/氯沙坦钾/尿微量蛋白Key words
diabetic nephropathy/beraprost sodium/losartan potassium/microalbuminuria分类
医药卫生引用本文复制引用
田江宣,陈日秋,季晓珍,官常荣..贝前列素钠联用氯沙坦钾对糖尿病肾病早期患者的临床研究[J].中国临床药理学杂志,2016,32(1):15-17,3.基金项目
浙江省丽水市重点学科建设基金资助项目(LSKJ2011008) （LSKJ2011008）
