中国临床药理学杂志2016，Vol.32Issue(1)：21-23,3.DOI:10.13699/j.cnki.1001-6821.2016.01.007
精神分裂症脑源性神经营养因子基因C270 T多态性与利培酮临床疗效的关联性研究
Association between brain - derived neurotrophic factor gene C270T polymorphisms and the clinical efficacy of resperidone in schizophrenia
摘要
Abstract
Objective To explore the association between brain derived neurotrophic factor ( BDNF ) gene C270 T polymorphisms and the clinical curativeeffectsofrisperidoneinschizophreniapatients.Methods 104 first episode schizophrenia patients were divided into C /C group ( n=65 ) and C/T +T/T group ( n =39 ) according to C270 T gene polymor-phisms.All of them were treated with resperidone , the dosage was adjus-ted according to the status of disease but the largest was not more than 8 mg· d -1 .Positive and negative syndrome scale ( PANSS) was used to assess psychotic symptoms before treatment and 1 month after treatment. The improvement of PANSS between two groups was compared .Results The distribution of C270T gene polymorphisms was C/C type 65 (62.5%), C/T type 36 (34.6%), T/T type 3 (2.9%).Allele gene:C 166 ( 79.8%) , T 42 ( 20.2%) .There was no statistical difference of PANSS score before and after treatment ( P>0.05 ).After 1 month treat-ment, both groups got a significant improvement of PANSS score (P<0.05), and the C/C group had a higher reducing rate of PANSS and the subscales of PANSS ( P <0.05 ) .Conclusion Risperidone shows its therapeutic effect for all of the C 270 T subtypes schizophrenia patients , and it is much better for C/C type but not the C/T+T/T type.关键词
精神分裂症/脑源性神经营养因子/C270T多态性/利培酮Key words
schizophrenia/brain derived neurotrophic factor/C270 T polymorphism/resperidone分类
医药卫生引用本文复制引用
张开元,宋明芬,陶云海,朱春燕,章隆,董介正,陈海萍,施剑飞..精神分裂症脑源性神经营养因子基因C270 T多态性与利培酮临床疗效的关联性研究[J].中国临床药理学杂志,2016,32(1):21-23,3.基金项目
浙江省自然科学基金资助项目(LQ13H090003) （LQ13H090003）
杭州市卫生科技重点项目基金资助项目(2014Z10) （2014Z10）
杭州市科技发展计划项目重点专科专病科研攻关基金资助项目(21030733Q26,20130733Q27) （21030733Q26,20130733Q27）
