中国临床药理学杂志2016，Vol.32Issue(1)：30-32,3.DOI:10.13699/j.cnki.1001-6821.2016.01.010
细胞色素P4502 C9在中国朝鲜族健康人群的基因多态性分布研究
Study of cytochrome P450 2C9 gene polymorphism in healthy Chinese Korean
摘要
Abstract
Objective To investigate the drug -metabolizing enzyme gene cytochrome P450 2C9 ( CYP2C9 ) distribution in Chinese Korean healthy population .Methods Two hundred healthy volunteers from Chi-nese Korean were recruited .A polymerase chain reaction -restriction fragment length polymorphism ( PCR-RFLP) method was developed to detect CYP2 C9*2 and *13 allele frequencies and compare genetic po-lymorphism differences with other ethnic groups from literatures .Results Six cases of CYP2C9 *1/*2 mutation individuals , 1 case of CYP2C9*2/*2 mutation individual and 1 case of CYP2C9*1/*13 mutated individuals in Korean health subjects were found in this study . The allele frequencies of CYP2C9*2 and *13 gene were 2.98% and 0.37%respectively.The results showed that there were similar ethnic in the distribution of CYP2C9 in Chinese Korean and Mongolian. Conclusion The results showed that Chinese Korean existed CYP 2C9 gene polymorphism distribution , and the distribution was similar to the Mongolian in Chifeng region .关键词
细胞色素P4502C9/细胞色素P4502C9*2/细胞色素P4502C9*13/基因多态性/聚合酶链反应-限制性内切酶片段长度多态/朝鲜族Key words
cytochrome P450 2C9/cytochrome P450 2C9*2/cyto-chrome P450 2 C9*13/polymorphism/polymerase chain reaction -restriction fragment length polymorphism/Korean分类
医药卫生引用本文复制引用
李爽,吴秀君,张媞,刘美,肇丽梅..细胞色素P4502 C9在中国朝鲜族健康人群的基因多态性分布研究[J].中国临床药理学杂志,2016,32(1):30-32,3.基金项目
"重大新药创制"科技重大专项"十二五"第二批基金资助项目(2012ZX09303015) （2012ZX09303015）
