中国临床药理学杂志2016，Vol.32Issue(1)：62-64,3.DOI:10.13699/j.cnki.1001-6821.2016.01.020
四逆散镇静催眠作用的药理学实验研究
Experimental study on the effects of freeze-dried powder of Si-Ni-San on sleep time
摘要
Abstract
Objective To study on the effects of freeze -dried powder of Si-Ni -San on sleep time.Methods One hundred and sixty mice were divided into three groups ,namely the control group ,model group and Si-Ni-San freeze-dried powder group .The mice in the Si-Ni-San group was received oral administration of 12 g· kg of drugs,the control group received an equal volume of distilled water ,one time each day for continuous 7 d.The effects of Si-Ni-San freeze-dried powder on the sleep phases of normal rats and insomnia model rats induced by polysom-nography and electrical stimulation induced were analyzed by electroencephalography analysis.Results The Si -Ni -San freeze -dried power can significantly prolong the sleep time of insomnia mice in-duced by pentobarbital sodium .The slow -wave sleep 2 ( SWS2 ) and rapid-eye-movement sleep ( REMS) were prolonged after the rats were orally administrated of freeze -dry powder of Si -Ni -San for seven days.Conclusion Freeze-dry powder of Si-Ni-San can significant-ly prolong pentobarbital of the threshold dose sodium -induced sleeping time in mice.关键词
四逆散冻干粉/改善睡眠/睡眠时相/戊巴比妥钠Key words
freeze-dry powder of Si -Ni-San/improve sleep/sleep phase/pentobarbital sodium分类
医药卫生引用本文复制引用
李越峰,牛江涛,曹瑞,徐富菊,张泽国,严兴科..四逆散镇静催眠作用的药理学实验研究[J].中国临床药理学杂志,2016,32(1):62-64,3.基金项目
国家自然科学基金资助项目(81460611) （81460611）
教育部科学技术研究重点基金资助项目(212186) （212186）
甘肃省自然科学基金资助项目(2010:1010RJZA212 （）
2014:145RJZA076) （）
甘肃省财政厅高校基本科研业务费专项基金资金项目(2013-2) （2013-2）
甘肃省中医药管理局科研课题基金资金项目(GZK-2015-57) （GZK-2015-57）
兰州市科技局基金资金项目(2014-1-188) （2014-1-188）
