中国临床药理学杂志2016，Vol.32Issue(1)：72-74,3.DOI:10.13699/j.cnki.1001-6821.2016.01.023
阿托伐他汀在急性缺血性脑卒中患者中的临床研究
Clinical effects of atorvastatin in patients with acute ischemic stroke
摘要
Abstract
Objective To explore the clinical effects of two doses of atorvastatin in patients with acute ischemic stroke .Methods A total of 128 patients with acute ischemic stroke were randomly divided into two groups ,64 cases in each group .The patients in atorvastatin 20 mg group were given atorvastatin 20 mg daily , and the patients of the atorvastatin 10 mg group were given atorvastatin 10 mg daily.The treatment lasted for six months.Blood lipid , nerve function defect grading , atherosclerotic plaque area and adverse drug reactions were observed before and after six months.Results The total effective rate in the atorvastatin 20 mg group (98.4%) was significantly higher than that in the atorvastatin 10 mg group (84.4%) (P<0.05).Blood lipid, nerve function defect grading and atherosclerotic plaque area were obviously improved in two groups (P<0.05), and the atorvastatin 20 mg group had a better improvement against the atorvastatin 10 mg group ( P <0.05 ) . The incidence of adverse drug reactions in two groups were 4.7%, no statistical signifi-cance (P>0.05).Conclusion Aatorvastatin 20 mg can better improve the clinical symptoms , blood lipid level as well as atherosclerotic plaque area in patients with acute ischemic stroke , accordingly improve the quality of life in those patients .关键词
急性缺血性卒中/不同剂量/阿托伐他汀/临床效果Key words
acute ischemic stroke/different dose/atorvastatin/clinical effect分类
医药卫生引用本文复制引用
周红霞,王兴元,范利娟,杨善进,曹洪兵,吴占敖..阿托伐他汀在急性缺血性脑卒中患者中的临床研究[J].中国临床药理学杂志,2016,32(1):72-74,3.基金项目
全军医药卫生科研基金资助项目(ZX13) （ZX13）
