中国全科医学2016，Vol.19Issue(1)：54-58,5.DOI:10.3969/j.issn.1007-9572.2016.01.010
糖尿病前期人群血脂特点及其对糖尿病前期转归的影响研究
Characteristics of Blood Lipid Level of Prediabetes Patients and Its Influence on Patients′Outcome
摘要
Abstract
Objective To investigate the characteristics of blood lipid level of patients with prediabetes and explore the influence of blood lipid level on patients′outcome.Methods Using cluster random sampling method , we enrolled 4 000 residents in Qiancao, Dashanping and Longmatan communities from April to November in 2011.A total of 1 090 residents were detected with prediabetes, and these patients were divided into three groups: pure impaired fasting glucose (IFG) group (n=79), pure impaired glucose tolerance (IGT) group (n=856) and IFG+IGT group (n=155) .Baseline data and three -year follow-up were conducted on patients with prediabetes , and comparison was made among the three groups in blood lipid level , prevalence of dyslipidemia , outcome after three -year follow -up and baseline data of patients with different outcomes .The influence of blood lipid on the outcome of patients with prediabetes was also analyzed .Results IFG+IGT group was higher than IGT group in TC level, and was higher than IFG group and IGT group in TG level and lower in HDL-C level than IFG group (P<0.05); IFG+IGT group was higher in the prevalence of high TG level than IFG group and IGT group (P<0.016 7).After three -year follow-up, the numbers of patients who had an outcome of normal sugar tolerance , IFG, IGT, IFG+IGT and diabetes were 395, 32, 419, 56 and 188.The three groups were significantly different in outcome (χ2 =41.579, P<0.001), the yearly conservation rates to diabetes from IFG , IGT and IFG+IGT were 4.2%, 5.0% and 10.5% respectively.The patients with an outcome of diabetes were higher than the patients with an outcome of normal glucose tolerance in baseline age , BMI, waistline, hipline, systolic pressure, glycosylated hemoglobin, fasting blood glucose, OGTT 2 h blood glucose, TG level and family history of diabetes proportin , history of alcoholic consumption proportion ( P<0.05 ) .TG level was a risk factor for diabetes outcome from prediabetes.After the adjustment of gender , age, BMI, waistline, hipline, the family history of diabetes , the history of smoking , the history of alcoholic consumption , systolic pressure , glycosylated hemoglobin , fasting blood glucose and OGTT 2 h blood glucose and compared with the minimum interquartile range (TG1 0.35~0.98 mmol/L), the OR (95%CI) of the maximum interquartile range (TG4 2.08~11.70 mmol/L) was 1.285 (1.067, 2.151), P =0.045.Conclusion Patients with prediabetes have different degrees of dyslipidemia , mainly in the form of high TG level .Patients with IFG+IGT have high conversation rate to diabetes; TG has influence on the outcome of patients with prediabetes and may be a potential predictor for the diabetes outcome of prediabetes patients .关键词
糖尿病前期/血脂/糖尿病/转归Key words
Prediabetic state/Blood lipids/Diabetes mellitus/Outcome分类
医药卫生引用本文复制引用
赵娅,万沁..糖尿病前期人群血脂特点及其对糖尿病前期转归的影响研究[J].中国全科医学,2016,19(1):54-58,5.基金项目
国家代谢性疾病临床医学研究中心资助项目(2013BAI09B13) （2013BAI09B13）
