中国实用外科杂志2016，Vol.36Issue(1)：106-110,5.DOI:10.7504/CJPS.ISSN1005-2208.2016.01.28
谷氨酰胺治疗对有营养风险肝胆手术病人临床结局影响研究
Influences of glutamine in hepatobiliary surgery patients with nutritional risk
摘要
Abstract
Objective To observe the incidence of patient's nutritional risk in hepatobiliary surgery.,and analyse the influences of glutamine treatment on these patients. Methods By continuously collecting the patients' data, who have been conducted the operation in general surgery of hospital of Guangzhou Military Command with the method of cohort study from January 2011 to December 2011. Including patients with NRS≥3, graded by NRS2002 scoring criteria. 402 cases of patients in total, 248 cases using glutamine treatment and 154 cases non glutamine treatment. Observing the hospital stay and incidence of infectious complications.Results The number of patients with infectious complications is 9 cases in glutamine group, and 14 cases in non glutamine group respectively(P<0.05);The hospital stay is(11.28 ± 7.77 )d&(12.03 ± 9.02 )d(P>0.05). For the patients with NRS≥3, 4cases with infectious complications and 6 cases with glutamine group(130 cases)and non glutamine group(47 cases), the hospital stay is(11.21 ± 7.15)d &(12.73 ± 1.26)d(P<0.05). The results of logistic regression analysis suggest that glutamine is the protective factors. However, NRS≥5, preoperative elevated GGT and preoperative lower prealbumin are independent risk factors, the OR values were 0.76, 1.19, 1.25 & 1.39 respectively, and P<0.05. Conclusions Glutamine can significantly reduce the incidence, shorten the hospital stay for patients in hepatobiliary surgery with nutritional risk, and the patients with NRS≥5 can benefit more from glutamine treatment.关键词
肝胆手术/营养风险/谷氨酰胺Key words
hepatobiliary surgery/nutritional risk/glutamine分类
医药卫生引用本文复制引用
刘升辉,卢绮萍,曹廷加,胡帆,李勇,陈惟..谷氨酰胺治疗对有营养风险肝胆手术病人临床结局影响研究[J].中国实用外科杂志,2016,36(1):106-110,5.基金项目
中国博士后科学基金资助项目(No.2014M552709) （No.2014M552709）
