中国实用外科杂志2016，Vol.36Issue(1)：122-125,4.DOI:10.7504/CJPS.ISSN1005-2208.2016.01.32
青年女性乳腺癌临床病理学特点及预后相关因素分析
Analysis on clinicopathological characteristics and prognostic factors of breast cancer in young women
摘要
Abstract
Objective To explore the clinical and pathological characteristics of breast cancer in young women(<35 years old)and to analyze their association with treatment and prognosis. Methods The records of 110 breast cancer in young women treated from January 2008 to December 2014 were reviewed. Statistical methods were used for analyzing the correlation between clinical and pathological characteristics such as T-stage, N-stage, IHC (Immunohistochemistry) and the morbidity as well as prognosis. The clinical and pathological characteristics of breast cancer in young women were compared with patients ≥35years using the χ2 test. Kaplan-Meier curves were reported for OS (overall survival) and PFS (progression-free survival), and the log-rank test was used to compare the difference in groups. Cox proportional models were fitted for multivariate analysis. Results All of the patients were women and the median age was 32 (21 to 34)-year old, accounted for 5.71%(110/2189) of the breast cancer treated at the same period. The morbidity of Luminal A-like and Luminal B-like(HER2 negative) in <35-year group were higher than ≥35-year group(P<0.001). Patients<35 years chose breast-conserving or mastectomy combined reconstruction surgery were much more than older group(P<0.001). The median follow-up duration of breast cancer in young women was 31.5 months, the 5-year OS rate was 93.3%and the 5-year PFS rate was 89.3%. It is concluded that the N-stage(P<0.001)and M-stage(P<0.001)were the influencing factors of the PFS by multivariate Cox regression analysis. The N-stage(P<0.001)was the influencing factor of OS. Conclusion Breast cancer in young women had special clinical and pathological characteristics. The endocrine therapy should be strengthened as well as protecting fertility. Patients<35 years demanded high quality of life and appearance, and the option of surgical treatment should be personalized.关键词
青年女性乳腺癌/临床病理学特征/个体化治疗Key words
breast cancer in young women/clinical and pathological characteristics/personalized therapy分类
医药卫生引用本文复制引用
高国璇,于大鹏,张虹,张爽,徐玲,叶京明,李挺,段学宁,刘荫华..青年女性乳腺癌临床病理学特点及预后相关因素分析[J].中国实用外科杂志,2016,36(1):122-125,4.基金项目
首都特色应用研究项目(No.Z131107002213007) （No.Z131107002213007）
