中国药理学通报Issue(12)：1637-1640,4.DOI:10.3969/j.issn.1001-1978.2015.12.003
微管抑制剂诱导肿瘤细胞有丝分裂灾难研究进展
Research progress of microtubule inhibitor-induced tumor cell mitotic catastrophe
摘要
Abstract
Microtubule inhibitor has been a hot area of anticancer drugs research.Microtubule inhibitor exert an anti-tumor effect by promoting or inhibiting the microtubule aggregation to break the dynamic balance of microtubule,hindering the spindle forma-tion of tumor cells,and then blocking the process of cell divi-sion.Mitotic catastrophe is a cell death phenomenon that is caused by abnormal cell division and damage of spindle structure in cell mitosis phase.In recent years more and more attention has been paid to mitotic catastrophe cell death because it has <br> been confirmed clinically that microtubule inhibitors can induce mitotic catastrophe death of tumor cells.This paper reviews the latest research progress of microtubule inhibitors,and discusses the molecular mechanisms of mitotic catastrophe cell death tumor cells induced by microtubule inhibitors.关键词
微管抑制剂/微管蛋白聚合剂/微管蛋白解聚剂/有丝分裂灾难/纺锤体组装检查点/分子机制Key words
microtubule inhibitor/tubulin polymerization agent/tubulin depolymerization agent/mitotic catastrophe/spindle as-sembly checkpoint/molecular mechanism分类
医药卫生引用本文复制引用
邹翔,王超,曲中原,方月妮,盛洁静,季宇彬..微管抑制剂诱导肿瘤细胞有丝分裂灾难研究进展[J].中国药理学通报,2015,(12):1637-1640,4.基金项目
国家自然科学基金资助项目（No 81102858）；黑龙江省普通本科高等学校青年创新人才培养计划（No UNPYSCT-2015070）；中国博士后科学基金项目（No 2013M321060）；黑龙江省博士后科研基金项目 （）
