中国药理学通报Issue(12)：1646-1651,6.DOI:10.3969/j.issn.1001-1978.2015.12.005
细胞因子信号转导抑制分子-3在肝纤维化中的作用及研究进展
Research progress of role of SOCS-3 in treating liver fibrosis
摘要
Abstract
Liver fibrosis occurs as compensatory responses to tis-sue repairing process in a wide range of chronic liver injures.It is characterized by excessive deposition of extracellular matrix (ECM)in liver tissues.The new discovery shows that suppres-sor of cytokine signaling (SOCS-3)is strictly associated with fi-brogenic progression of chronic liver diseases.Recent basic and clinical investigations also demonstrate that liver fibrogenesis is accompanied by SOCS-3,which critically determines the patho- <br> genesis and prognosis of liver fibrosis.This review summarizes current knowledge on SOCS-3 and the relationships between SOCS-3 and liver fibrosis.On the other hand,it also presents the different strategies that have been used in experimental mod-els to counteract excessive SOCS-3 and the role of SOCS-3 in the prevention and treatment of liver fibrosis.关键词
SOCS-3/肝纤维化/作用机制/信号通路/细胞外基质/肝星状细胞Key words
SOCS-3/liver fibrosis/mechanism/signal path-way/extracellular matrix/hepatic stellate cell分类
医药卫生引用本文复制引用
张自力,赵士峰,许文萱,张峰,吴丽,陆茵,郑仕中..细胞因子信号转导抑制分子-3在肝纤维化中的作用及研究进展[J].中国药理学通报,2015,(12):1646-1651,6.基金项目
国家自然科学基金资助项目（No 81270514，31401210，31571455）；江苏省自然科学基金青年基金资助项目（No BK20140955）；江苏省高校自然科学研究面上项目资助项目（No 14KJB310011）；江苏高校优势学科建设工程资助项目（No ysxk-2010）；江苏高校优秀科技创新团队计划 （）
