中国药理学通报Issue(12)：1754-1759,6.DOI:10.3969/j.issn.1001-1978.2015.12.025
越鞠丸石油醚部位潜在的快速抗抑郁作用与BDNF、TrkB 蛋白表达的上调相关
Potent rapid antidepressant effects of petroleum ether fraction of Yueju pill associated with BDNF and TrkB up-regulation
摘要
Abstract
Abstact:Aim To identify whether the petroleum e-ther fraction of Yueju pill (YJ-PE)could exhibit a po-tent rapid antidepressant effect and to investigate the underlying biological mechanism involved.Methods Fourty-four male KM mice were randomly assigned to five groups:the control group (saline group),low dosage of YJ-PE,middle dosage of YJ-PE,high dos-age of YJ-PE and ketamine.After a single drug admin-istration,we used tail suspension test (TST)to test the rapid antidepressant effect of YJ-PE in KMmice at 30 min.Another twenty-four male KM mice were ass-inged to three groups:control group,screened effective low dosage of YJ-PE group and ketamine group.We usd TST to assess these mice at 24 h post a single ad- <br> ministration.Western blot was performed to examine the expression of BDNF and TrkB in hippocampus of KMmice at 30 min and 24 h post a single administra-tion.Results An acute administration of YJ-PE de-creased the immobility time of KMmice in TST and in-creased the expression of BDNF and TrkB as soon as 30min post a single administration and lasted at least for 24 hours.Conclusion YJ-PE (low dosage)ex-hibits a rapid antidepressant-like potent,and the po-tent rapid antidepressant effects of YJ-PE are associat-ed with the up-regulation of BDNF and TrkB.关键词
越鞠丸/石油醚部位/快速抗抑郁/BDNF/TrkB/氯胺酮Key words
Yueju pill/petroleum ether fraction/rap-id antidepressant/BDNF/TrkB/ketamine分类
医药卫生引用本文复制引用
任荔,陶伟伟,薛文达,吴颢昕,陈刚..越鞠丸石油醚部位潜在的快速抗抑郁作用与BDNF、TrkB 蛋白表达的上调相关[J].中国药理学通报,2015,(12):1754-1759,6.基金项目
国家自然科学基金资助项目（No 81403041）；江苏省自然科学基金资助项目（No BK20151568）；江苏省高校优势学科支持项目 （）
