摘要
Abstract
Objective:To investigate the effect of linezolid on serum CRP and TNF-αlevels, and to analyze its clinical curative effect for MRSA pneumonia patients.Methods:62 patients with MRSA pneumonia were divided into 2 groups, 32 cases (treated with linezol-id) in the experimental group , and 30 cases ( treated with vancomycin ) in the control group in our hospital from April 2013 to March 2015 .Serum CRP and TNF-αlevels were compared between 2 groups before and after drug treatment , and the efficacy and adverse reac-tion of linezolid and vancomycin were observed .32 strains of MRSA isolated from the experimental group were induced in vitro , and then the changes of the drug resistance were observed .Results:The effective rate in the experimental group (87.5%) was significantly higher than the control group (60.0%), P<0.05.Serum CRP and TNF-αlevels were significantly decreased in 2 groups after treatment, P <0.05 .And serum CRP and TNF-αlevels in the experimental group were also significantly decreased than the control group , P<0.05. The therapeutic effects were evaluated by detecting the changes of serum CRP and TNF -αlevels, and the sensitivity was 93.5%(58/62) .The bacterial clearance rate in the experimental group ( 78.1%) was significantly higher than the control group ( 50.0%) after treat-ment, P<0.05,but there was no significant difference of adverse reaction rate between 2 groups.The minimum inhibitory concentration (MIC) of linezolid on MRSA changed little after 21 times induce in vitro, and the MIC value was 4 mg· L-1.Conclusion: Linezolid could significantly reduce the serum CRP and TNF-αlevels in MRSA pneumonia patients , and the therapeutic effects were evaluated by detecting the changes of serum CRP and TNF-αlevels.Linezolid was safe and effective , and linezolid hardly induced MRSA resistant against drug.Linezolid should be worthy of promotion and application in clinical with excellent characteristics .关键词
耐甲氧西林金黄色葡萄球菌/MRSA肺炎/利奈唑胺/万古霉素/C反应蛋白/肿瘤坏死因子/最低抑菌浓度/体外耐药诱导Key words
MRSA/MRSA pneumonia/Linezolid/Vancomycin/CRP/TNF-α/MIC/Alpha induced resistance in vitro分类
医药卫生
