中国医学装备Issue(12)：4-6,7,4.DOI:10.3969/J.ISSN.1672-8270.2015.12.002
成年人1型糖尿病酮症酸中毒治疗中电解质变化特点分析
Characteristic analysis on electrolyte changes during treatment of adult type 1 diabetic ketoacidosis
摘要
Abstract
Objective:To observe the characteristics of electrolyte changes during treatment of adult type 1 diabetic ketoacidosis and investigate the clinical significance.Methods: Retrospective analysis was done in 34 cases of type 1 diabetic ketoacidosis. Blood gases, electrolytes, renal function and other data during treatment were recorded.Results: (1)Levels of blood urea nitrogen, creatinine, uric acid, blood glucose and osmolality after treatment were lower than those before treatment(t=5.607,t=3.572,t=6.640,t=17.817,t=7.284;P<0.05). (2)Level of bicarbonate increased and levels of anion gap, potassium, magnesium, phosphate decreased during treatment(F=238.647,F=88.143,F=13.900,F=5.803, F=25.263;P<0.05), whereas the changes of sodium, chlorine and calcium had no statistic significance(F=1.858, F=1.527,F=2.164;P<0.05). (3)Bicarbonate and anion gap levels were significantly different between any two detected time points. Levels of potassium, magnesium and phosphate were significantly different in and after treatment compared respectively with those before treatment, whereas their levels were not significantly different in the treatment compared with those after treatment.Conclusion: Focusing on monitoring of blood electrolytes and making individual assessment during treatment of diabetic ketoacidosis may help to improve the prognosis.关键词
1型糖尿病/糖尿病酮症酸中毒/电解质Key words
Type 1 diabetes mellitus/Diabetic ketoacidosis/Electrolyte分类
医药卫生引用本文复制引用
王兴洲,张日东,石敏,高鹏霞,张红..成年人1型糖尿病酮症酸中毒治疗中电解质变化特点分析[J].中国医学装备,2015,(12):4-6,7,4.基金项目
国家自然科学基金(81200595)“肾脏GLP-1受体信号通路调节TGF-β1改善糖尿病肾病机制的研究” （81200595）
