摘要
Abstract
Objective To investigate the effect of different dose of remifentanil combined with propofol on hemodynamics in patients with laparoscopic operation by target controlled infusion(TCI). Methods 400 patients with laparoscopic operation in our hospital were divided into the control group and the observation group according to the random number method,200 cases in each group. The con-trol group was given 6. 0 μg/L remifentanil,and the observation group was given 8. 0 μg/L remifentanil,and the target plasma control dose of propofol was 3. 0 μg/L in the two groups. The changes of hemodynamics in two groups were observed and compared on before anesthesia(T0),skin incision(T1),after penumoperitoneum(T2),30 min after penumoperitoneum(T3),1 h after penumoperi-toneum(T4),end of penumoperitoneum(T5). Results The times of consciousness disappearance,anesthesia,breathing recovery and eye opening had no significant changes in the two groups( P > 0. 05);compared with T0,the bispectral index(BIS)on T1-T5 were sig-nificantly decreased in two groups( P < 0. 05);compared with the control group,the BIS on T1-T3 were significantly decreased in the observation group( P < 0. 05),the hear rate(HR) and mean arterial pressure(MAP) on T1-T5 were significantly decreased in the observation group( P < 0. 05). Conclusion The TCI of remifentanil(8. 0 μg/L) combined with propofol can significantly inhibit the BIS induced by laparoscopic operation,and maintain the stability of hemodynamics during the laparoscopic operation.关键词
瑞芬太尼/异丙酚/靶控输注/腹腔镜/血流动力学Key words
remifentanil/propofol/target controlled infusion/laparoscopy/hemodynamics分类
医药卫生
