中国中医药信息杂志Issue(1)：27-30,4.DOI:10.3969/j.issn.1005-5304.2016.01.006
益气活血解毒方对晚期卵巢癌患者免疫调节的影响
Effects ofYiqi Huoxue Jiedu Recipe on Immunomodulatory of Patients with Advanced Ovarian Cancer
摘要
Abstract
Objective To study the effects ofYiqi Huoxue Jiedu Recipe on immunomodulatory of patients with advanced ovarian cancer.Methods It was performed in a single-arm, open-label study with 40 patients with advanced epithelial ovarian cancer. All patients were treated withYiqi Huoxue Jiedu Recipe lasting for 4 weeks (200 mL, twice a day). The main endpoint was the quantities of CD4+CD25+ cells, CD8+CD28- regulatory T cells and CD8+CD28+ cytotoxic T cells measured by flow cytometry, and the accessory endpoints were variations of symptoms which included pain, fatigue, and numbness etc.Results The quantities of CD4+CD25+ and CD8+CD28- cells significantly decreased compared with those of pre-treatment (P<0.05); the quantity of CD8+CD28+ cell increased significantly (P<0.05). Except for pain, significant improvement showed in fatigue, tinnitus, numbness, poor appetite, abdominal discomfort, insomnia, diarrhea and abnormal urinate (P<0.05).ConclusionYiqi Huoxue JieduRecipe is proved to be effective in regulating immunosuppression advanced ovarian cancer and improving patients’ life quality.关键词
晚期卵巢癌/益气活血解毒方/调节性T细胞/生活质量Key words
advanced ovarian cancer/Yiqi Huoxue Jiedu Recipe/regulatory T cells/life quality分类
医药卫生引用本文复制引用
闫会苓,马丹,卢雯平..益气活血解毒方对晚期卵巢癌患者免疫调节的影响[J].中国中医药信息杂志,2016,(1):27-30,4.基金项目
国家自然科学基金 （）
