中南民族大学学报（自然科学版）Issue(4)：15-18,4.
N＇-（2-羟基-5-溴苯甲酰胺基）-2-亚胺基-4-噻唑烷酮的合成及生物活性
Synthesis and Biological Activity of N'-(2-Hydroxy-5-Bromobenzoylamino)-2-Imino-4-Thiazolidinone
摘要
Abstract
5-bromo- salicylicacid was used to synthesize 5-bromo-methyl salicylate,which further reacted with hydrazine hydrate to obtain 5-bromosalicylaldehyde hydrazide. The 5-bromosalicylaldehyde hydrazine then reacted with potassium thiocyanate to form 5-bromosalicylaldehydethiosemicarbazides, which finally reacted with ethyl bromoacetate proceededcatalytic to afford N'-( 2-hydroxy-5-bromobenzoylamino )-2-imino-4-thiazolidinone. The structure of the final compound was characterized by IR,element analysis,1 H NMR,and 13 C NMR. The compound also showed good anti-inflammatory and antibacterial activity.关键词
N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮/表征/抗炎活性/抗菌活性Key words
synthesis/N'-(2-hydroxy-5-bromobenzoylamino)-2-imino-4-thiazolidinon/characterization/anti-inflammatoryactivity/antibacterial activity分类
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金龙飞,李培娟,亢子珍,范昕,张健..N＇-（2-羟基-5-溴苯甲酰胺基）-2-亚胺基-4-噻唑烷酮的合成及生物活性[J].中南民族大学学报（自然科学版）,2015,(4):15-18,4.基金项目
湖北省自然科学基金重点项目 （）
