北华大学学报（自然科学版）2016，Vol.17Issue(1)：47-50,4.DOI:10.11713/j.issn.1009-4822.2016.01.011
北五味子与人参共煎剂对老年大鼠尿液代谢组学的影响
Effects of Schisandra-Ginseng Elixation on the Urine Metabolites in Aging Rats
摘要
Abstract
Objective To study the effects of the elixation of Schisandra-Ginseng ( ESG ) on the urinary metabolits in aging rats. Method A metabonomics approach based on rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry ( RRLC-Q-TOF-MS) method was applied to analyze the characteristics of urine samples of Wistar rats ( 24 month-old ) before and after ESG treatment. Principal component analysis ( PCA) was carried out for the pattern recognition and the analysis of metabolites of urine samples, and to find biomarkers. The biomarkers were identified by MS/MS analysis and referring to authentic chemicals. Results A total of 5 potential biomarkers were found and identified in the urine samples of Wistar rats (24 month-old) before and after ESG treatment. The analysis on metabolic pathways indicated that energy metabolism, 5-HT related metabolite and lipid metabolism changed after ESG treatment. Conclusion The experiment demonstrated that ESG plays roles of anti-fatigue,reducing fat,antioxidation and delaying brain aging by affecting energy metabolism,5-HT related metabolite and lipid metabolism.关键词
北五味子/人参/代谢组学/代谢产物Key words
Schisandra chinensis/Ginseng/metabonomics/metabolite分类
医药卫生引用本文复制引用
郭威,孙伟静,李贺,王春梅,孙红霞,张成义,陈建光,孙靖辉..北五味子与人参共煎剂对老年大鼠尿液代谢组学的影响[J].北华大学学报（自然科学版）,2016,17(1):47-50,4.基金项目
吉林省科技发展计划项目(YYZX2011243) （YYZX2011243）
吉林省卫生厅青年科研基金项目(2013Q017) （2013Q017）
吉林市科技发展计划项目(201464062). （201464062）
