北华大学学报（自然科学版）2016，Vol.17Issue(1)：54-57,4.DOI:10.11713/j.issn.1009-4822.2016.01.013
FOXP3在人肺腺癌细胞中的表达意义
Clinical Value of FOXP3 Expression in Human Lung Adenocarcinoma Cells
摘要
Abstract
Objective To explore the role and clinical value of FOXP3 in lung adenocarcinoma,by detecting the expression of FOXP3 protein in the tumor cells of primary lung adenocarcinoma. Method A total of 42 cases specimens from the operated patients with primary lung adenocarcinoma were selected in this study with 15 cases of normal lung tissue as control. FOXP3 expression was detected by immunohistochemistry technique ( SP method ) and the relationship between FOXP3 expression and clinicopathological features were analyzed. Results The positive expression rate of FOXP3 was 64. 3% in lung adenocarcinoma,which was significantly higher than that of the control group with 20. 0% (P=0. 011). FOXP3 expression in lung adenocarcinoma was closely associated with lymph node metastasis. The positive rate of FOXP3 in the lymph node metastasis group (83.3%)was significantly higher than that of the non-lymph node metastasis group (50. 0%)(P=0. 026). While no correlation was found between the expression of FOXP3 and the patients' gender,age,tumor size and differentiation ( P >0. 05 ). Conclusion FOXP3 may play an important role in the tumorigenesis and development of lung adenocarcinoma. Therefore, FOXP3 could be used as one of the markers to evaluate the malignant biological behavior of lung adenocarcinoma.关键词
FOXP3/肺腺癌/免疫组化Key words
FOXP3/lung adenocarcinoma/immunohistochemistry分类
医药卫生引用本文复制引用
陈立松,马绪哲,王英楠,谢姝,盖晓东,历春..FOXP3在人肺腺癌细胞中的表达意义[J].北华大学学报（自然科学版）,2016,17(1):54-57,4.基金项目
吉林省科技厅自然科学基金项目(20150101128JC). （20150101128JC）
