化工进展Issue(1)：227-238,12.DOI:10.16085/j.issn.1000-6613.2016.01.031
甜味剂三氯蔗糖合成法的最新进展
Progress in synthesis of food sweetener sucralose
摘要
Abstract
With the improvement of life quality,there has been an increasing demand on high quality and high safety food sweeteners. Sucralose is exactly such an ideal artificial sweetener,which has the features of non-nutritive,low-calorie,high sweetness,high safety,and good flavor. Therefore,it is extremely necessary to study the synthetic methods of sucralose. This paper mainly summarizes the recent progress in the synthetic methods of sucralose,and comprehensive evaluation is given. It is concluded that,while the omni-group protection method contains too many synthetic steps and the mono-group protection method of the acetic anhydride method and trimethyl orthoacetate method are still in development, the organotin method has fewer synthetic steps and the organotin can be recycled, therefore it is considered to be the most applicable in industrial production so far. On the other hand, chemical-enzyme synthetic method,especially the sucrose method,is believed to be the most promising one in the future due to its environment friendly and high selectivity aspect. In addition, there are some other synthetic methods,such as enzymatic hydrolysis of sucralose-6-ester,etc.,worthy of further research. Finally,the research trends are also discussed and several development suggestions are proposed.关键词
三氯蔗糖/甜味剂/全基团保护法/单基团保护法/酶-化学联合法Key words
sucralose/sweetener/omni-group protection method/mono-group protection method/chemical- enzyme synthetic method分类
轻工纺织引用本文复制引用
吴红英,鲍宗必,张治国,任其龙,邢华斌,杨亦文..甜味剂三氯蔗糖合成法的最新进展[J].化工进展,2016,(1):227-238,12.基金项目
国家自然科学基金（21222601）、教育部新世纪优秀人才支持计划（ NCET-13-0524）和浙江省重点科技创新团队计划（2011R50002）项目。 （）
