检验医学与临床Issue(1)：8-10,3.DOI:10.3969/j.issn.1672-9455.2016.01.004
58例抗线粒体抗体 M2亚型阳性患者检测结果分析
Analysis of detection results of 5 8 cases of antimitochondrial antibody subtype M2 positive
摘要
Abstract
Objective To study the significance of antimitochondrial antibody(AMA)subtype M2 in the early prevention,diagnosis and treatment of primary biliary cirrhosis (PBC).Methods 58 cases of AMA-M2 positive were selected as the observation group and divided into the group A(M2 positive and M4,M 9 negative,39 cases),B(M4 positive,4 cases),C (M2 positive and M9 positive,6 cases)and D (M2,M4 and M9 positive,9 cases).Contempora-neous 30 healthy individuals of physical examination as the control group.Western blot was used to detect serum AMA-M2.The immunoblotting method was used to detect the M2,M4 and M9 in the patients with AMA-M2 posi-tive.The automatic biochemical analyzer was applied to detect serum ALT,AST,ALP,γ-GT,TBIL and DBIL. Results The ALP,γ-GT,TBIL,DBIL,ALT and AST levels had the statistical difference between the observation group and the control group (P <0.05).The levels of biochemical indicators had statistical difference among different AMA subsets(P <0.05).Conclusion AMA-M2 can serve as a screening index for PBC,and the combined detection of M2,M4 and M9 could conduce to the early diagnosis and condition assessment of PBC.关键词
抗线粒体抗体/胆汁淤积/原发性胆汁性肝硬化Key words
antimitochondrial antibody/screening/primary biliary cirrhosis引用本文复制引用
彭雪莲,史静,邹麟,董剑,王丹..58例抗线粒体抗体 M2亚型阳性患者检测结果分析[J].检验医学与临床,2016,(1):8-10,3.基金项目
国家临床重点专科建设项目[财社(2010)305]。 （2010）
