检验医学与临床Issue(1)：31-32,2.DOI:10.3969/j.issn.1672-9455.2016.01.013
150例青海地区非小细胞肺癌患者表皮生长因子受体突变状态分析∗
Analysis on EGFR mutation status in 1 5 0 cases of non-small cell lung cancer in Qinghai region
摘要
Abstract
Objective To explore the mutation status of epidermal growth factor receptor (EGFR)during the treatment process of non-small cell lung cancer(NSCLC)in Qinghai region.Methods The real-time fluorescence Taqman probe method was used and the PCR amplification in vitro was adopted.The clinical characteristics and EG-FR mutation status in 1 50 cases of advance NSCLC were retrospectively analyzed.Results In the sample detection of 1 50 NSCLC cases,EGFR mutation (exon18 )was in 2 cases with the mutation rate of 1.3%;EGFR mutation (exon1 9)was in 18 cases with the mutation rate of 12.0%;EGFR (exon20)was not detected;EGFR mutations (ex-on 21)was in 27 cases with the mutation rate of 18.0%.Conclusion The mutation rate of EGFR gene exon 1 9 and 21 (somatic mutation)is higher in NSCLC patients of Qinghai region.The EGFR-TKIs treatment is acceptable.关键词
非小细胞肺癌/表皮生长因子受体/突变Key words
non-small-cell lung cancer/epidermal growth factor receptor/mutation引用本文复制引用
卢天龙,杨启英..150例青海地区非小细胞肺癌患者表皮生长因子受体突变状态分析∗[J].检验医学与临床,2016,(1):31-32,2.基金项目
青海省(应用)基础研究计划项目(2013-Z-735)。 （应用）
