摘要
Abstract
Objective To investigate the clinical effect of 1 3 1 I combined with liver protecting drugs for the treatment of Graves hyperthyroidism complicating liver injury.Methods 133 cases of Graves hyperthyroidism com-plicating liver injury in our hospital were chosen and randomly divided into the study group(67 cases)and the control group(66 cases).The control group was only treated with 1 3 1 I,while the study group was treated by 1 3 1 I combined with liver protecting drugs.The changes of FT3,FT4,TSH,TBIL,ALT and AST before treatment and at 1,3,6 months after treatment,and the treatment effective rates were compared between the two groups.Results After 1, 3,6 months treatment,the serum levels of FT3 and FT4 in the two groups were significantly lower than those before therapy (P <0.05),while the serum level of TSH was higher than that before treatment (P <0.05),but the serum levels of FT3,FT4 and TSH had no statistically significant difference between the two groups (P >0.05 );after 1-month treatment,the serum level of TBIL,ALT,AST in the control group had no statistically significant difference compared with those before treatment (P >0.05),while the serum levels of TBIL,ALT and AST in the study group were lower than those before therapy and the control group(P <0.05);after 3,6 months treatment,the serum levels of TBIL,ALT and AST in the two groups were significantly lower than those before therapy(P <0.05 ),moreover the study group was lower than the control group (P <0.05);the effective rate of hyperthyroidism had no statistical difference between the study group and the control group (98.5 1% vs .92.41%,P >0.05);the treatment effective rate of liver function in the study group was 95.52%,which was higher than 75.76% in the control group (P <0.05).Conclusion 1 3 1 I combined with liver protecting drugs are in treating Graves hyperthyroidism complicating liver injury has faster recovery of liver function,good curative effect,and is worth popularization.关键词
保肝药物/131I/甲状腺功能亢进/肝损害Key words
liver protecting drugs/1 3 1 I/hyperthyroidism/liver injury
