四川精神卫生Issue(6)：488-491,4.DOI:10.11886/j.issn.1007-3256.2015.06.002
精神分裂症患者基底节功能连接的静息态 fMRI 研究
Resting - state functional magnetic resonance imaging study of functional connectivity of basal ganglia in schizophrenia
摘要
Abstract
Objective To explore the difference of functional connectivity of basal ganglia in schizophrenia during a resting state by functional magnetic resoncance imaging(fMRI). Methods 3. 0T fMRI was used to assess the whole brain activity of 15 schizophrenia patients and 12 health controls. Functional connectivity analysis based on basal ganglia was performed to obtain the significant differ-ence between two groups. Results Compared with the health controls,the patients showed significantly increased functional connectiv-ity between media superior frontal gyrus,posterior cingulate and caudate;increased functional connectivity between left superior frontal gyrus,right anterior cingulate and left pallidum;increased functional connectivity between left medial frontal gyrus and right pallidum;increased functional connectivity between left superior frontal gyrus and left putamen. Conclusion This study discovers increased func-tional connectivity between basal ganglia and crucial regions of Default Model Network(DMN). The results imply that basal ganglia -DMN loop altered aberrantly,which might be associated with the pathological mechanisms of schizophrenia.关键词
精神分裂症/基底节/默认网络/功能磁共振Key words
Schizophrneia/Basal ganglia/Default Model Network(DMN)/Functional magnetic resoncance imaging(fMRI)分类
医药卫生引用本文复制引用
蒋宇超,陈琳,段明君,陈曦,杨宓,邓佳燕,赖永秀,尧德中,罗程..精神分裂症患者基底节功能连接的静息态 fMRI 研究[J].四川精神卫生,2015,(6):488-491,4.基金项目
国家自然科学基金 （）
