摘要
Abstract
Objective To investigate the clinical efficacy of paroxetine combined repetitive transcranial magnetic stimulation (rTMS)on patients with female climacteric depression. Methods A total of 72 patients of female climacteric depression were randomly divided into study group(36 cases)and control group(36 cases),the study group was treated with paroxetine combined rTMS, and the control group was treated with paroxetine. The efficacy was assessed with Hamilton Depression Scale - 17 item(HAMD - 17), Hamilton Anxiety Scale(HAMA)and Center for Epidemiological Survey,Depression Sale(CES - D)before treatment and after treat-ment for 1,2,4,6 weeks,adverse effect was evaluated with Treatment Emergent Symptom Scale(TESS). Results The effective rate were 94. 4% and 75. 0% in study group and control group,respectively,the difference was statistically significant( P < 0. 01). Starting from the 1st weekend of treatment,the HAMD - 17,HAMA and CES - D scores of study group decreased significantly com-pared with the baseline(P < 0. 01). Starting from the 2nd weekend of treatment,the HAMD - 17,HAMA and CES - D scores of con-trol group decreased significantly compared with the baseline(P < 0. 01). There were significant differences in those scores between the two groups at the same time after treatment(P < 0. 01). By the end of the treatment,there was no significant difference in TESS score between the two groups(P > 0. 05). Conclusion Paroxetine combined with rTMS is as effective as paroxetine for the treatment of female climacteric depression patients,and takes effect earlier.关键词
重复经颅磁刺激/女性更年期抑郁症/帕罗西汀Key words
Repetitive transcranial magnetic stimulation/Female climacteric depression/Paroxetine分类
医药卫生
