上海针灸杂志Issue(1)：94-97,4.DOI:10.13460/j.issn.1005-0957.2016.01.0094
针刺对睡眠剥夺大鼠学习记忆功能及前额叶皮质 BDNF 表达的影响
Influence of Acupuncture on Learning and Memorial Function and the Expression of BDNF in Prefrontal Cortex of Rats with Sleep Deprivation
摘要
Abstract
Objective To investigate the influence of acupuncture on learning and memorial function and the expression of BDNF in prefrontal cortex of rats with sleep deprivation (SD), for providing theoretical evidence for treating sleep deprivation with acupuncture.Method Sixty Wistar rats were randomly divided into a control group, a model group, and an acupuncture group, 20 rats in each group. SD models were established by the modified multiple platform methods; the acupuncture group was intervened by acupuncture at Shenmen (HT 7); while the control group was left intact. Respectively after SD for 24 h and 72 h, the learning and memorial function was tested by using Morris water maze. Ten the rats were sacrificed to collect brain for detecting the expression of BDNF in prefrontal cortex via immunohistochemical method.Result The body weight, learning and memorial function, and the expression of BDNF in prefrontal cortex of the acupuncture group and model group were significantly different from those of the control group after SD for 24 h and 72 h (P<0.05). The learning and memorial function of the acupuncture group was significantly different from that of the model group after SD for 24 h and 72 h (P<0.05). The body weight and expression of BDNF in prefrontal cortex of the acupuncture group were significantly different from those of the model group after SD for 72 h (P<0.05).Conclusion Acupuncture can obviously improve the decline of the function of learning and memory of the SD rats, and also up-regulate the declined expression of BDNF in prefrontal cortex caused by SD.关键词
针刺/睡眠剥夺/穴,神门/学习记忆功能/BDNF/大鼠Key words
Acupuncture/Sleep deprivation/Point, Shenmen (HT 7)/Learning and memorial function/BDNF/Rats分类
医药卫生引用本文复制引用
翟佳丽,陈松,田家星,张旭东,刘欢,刘川东,赵光涛..针刺对睡眠剥夺大鼠学习记忆功能及前额叶皮质 BDNF 表达的影响[J].上海针灸杂志,2016,(1):94-97,4.基金项目
滨州医学院大学生科技创新活动基金(BY2013DKCX082) （BY2013DKCX082）
