色谱Issue(1)：89-95,7.DOI:10.3724/SP.J.1123.2015.06036
β-环糊精／硅基杂化手性固定相的制备及其手性拆分性能
Preparation and enantioseparation performance ofβ-cyclodextrin-silica hybrid chiral stationary phases
摘要
Abstract
A simple preparation method for β-cyclodextrin-silica hybrid chiral stationary phases was developed. Firstly,the β-cyclodextrin-silica derivative was synthesized by the reaction of 3-aminopropyltriethoxysilane and monochlorotriazinyl β-cyclodextrin under weak base condi-tion. Spherical β-cyclodextrin-silica hybrid materials with β-cyclodextrin in the surface of pores by covalent bonding were prepared using 1,2-bis( triethoxysilyl)ethane and the β-cyclodextrin-silica derivative under the alkaline condition by one-step polymerization reaction. The β-Cyclo-dextrin-silica hybrid chiral stationary phases could be directly used as high performance liquid chromatographic packings after the template removal. The hybrid materials prepared in this paper possessed regular spherical morphology,good monodispersion,high specific surface area,good mechanical property,high chemical stability and simple preparation process. It combined the chiral recognition performance of β-cyclodextrin and the outstanding performance of organic-inorganic hybrid material. The effect of the composition,ratio and pH of mobile phase on chiral separation was investigated,and the best chiral separation conditions had been optimized. The baseline chiral separations for five chiral compounds were obtained under the optimal conditions. The results of enantioseparation showed that the hybrid chiral stationary <br> phases had favorable chiral recognition ability. Compared with the traditional preparation process of chiral stationary phases,a new thought for new type of chiral stationary phase is provided by the present method in this paper.关键词
高效液相色谱/手性固定相/β-环糊精/有机-无机杂化/手性拆分Key words
high performance liquid chromatography( HPLC)/chiral stationary phases/β-cy-clodextrin/organic-inorganic hybrid/enantioseparation分类
化学化工引用本文复制引用
王利涛,董树清,张志欣,王杨军,张晓莉,张霞,张鹏云,赵亮..β-环糊精／硅基杂化手性固定相的制备及其手性拆分性能[J].色谱,2016,(1):89-95,7.基金项目
国家自然科学基金项目（21405162，21405161）；乌鲁木齐市科技局重点项目（Y141320007）；阿拉善盟科技局沙产业科研项目．@@@@National Natural Science Foundation of China（21405162，21405161）；Key Projects of Urumqi Science and Technology Bureau（ Y141320007）；Deserticulture Projects of Alxa League Science and Technology Bureau． （）
