生物信息学Issue(4)：239-243,5.DOI:10.3969/j.issn.1672-5565.2015.04.06
调控胆固醇吸收的分子通路
Molecular pathways of cholesterol absorption regulation
摘要
Abstract
Cholesterol imbalance can cause a variety of diseases,such as high cholesterol,cardiovascular disease, while the cholesterol balance in body is maintained by synthesis, absorption, metabolism and circulation of cholesterol,and the absorption of cholesterol is a crucial step. Cholesterol absorption occurs mainly in the small intestine and proximal jejunum, and it is regulated by a number of proteins. Niemann⁃Pick C1⁃like 1 protein (NPC1L1) is responsible for the cholesterol uptake.ATP-binding cassette(ABC) G5/G8 inhibits the absorption of cholesterol. Acyl⁃coenzyme A( CoA):cholesterol acyltransferase( ACAT) catalyzes the cholesterol esterified reaction for raising cholesterol absorption.ATP⁃binding cassette transporters A1(ABCA1) transports cholesterol in peripheral tissues and these proteins are also affected by other regulatory factors. Parsing cholesterol absorption of molecular pathways has major directive significance the prevention and treatment of diseases related with cholesterol imbalance.Therefore, the molecular pathways of cholesterol absorption regulation were reviewed in this paper.关键词
胆固醇吸收/NPC1L1/ABCG5/G8/ACAT2/ABCA1Key words
Cholesterol absorption/NPC1L1/ABCG5/G8/ACAT2/ABCA1引用本文复制引用
邵翅,杨林..调控胆固醇吸收的分子通路[J].生物信息学,2015,(4):239-243,5.基金项目
国家自然科学基金（ No．31371755）。 （）
