实用肝脏病杂志Issue(1)：55-59,5.DOI:10.3969/j.issn.1672-5069.2016.01.014
慢加急性乙型肝炎肝衰竭患者贫血特点分析
Prevalence of anemia in patients with acute on chronic liver failure
摘要
Abstract
Objective To investigate the prevalence of anemia in patients with hepatitis B virus-induced acute-on-chronic liver failure (ACLF),and to evaluate its association with short-term survivals. Methods Hospitalized patients with HBV related acute-on-chronic liver failure,cirrhosis or chronic hepatitis B were recruited from December 2011 to January 2013 in this study. The peripheral blood index were routinely assayed. The prevalence and progression of anemia and clinical outcome of patients were observed. Results There were 171 patients included in this study. 2.5% out of 40 patients with chronic hepatitis B,34.7% out of 49 patients with liver cirrhosis and 45.1% out of 72 patients with ACLF had anemia at admission;and the percentages of mild,moderate and severe anemia in patients with ACLF were 26.8%,17.1% and 1.2%,respectively;Anemia in patients with ACLF exacerbated within first hospitalization week (122.4g/L vs. 112.7g/L,P=0.001);the blood hemoglobin levels in survived patients with ACLF (n=42) increased (112.7 g/L vs. 147.5 g/L,P=0.001);Blood hemoglobin levels in patients with ACLF at admission (cut-off value was 125.5 g/L) was an predictor for 90-day survivals (AUROC=0.735,P<0.001). Conclusions Anemia in patients with ACLF is common and severe,which might aggravate within one week and recover in survivals.关键词
慢加急性肝衰竭/乙型肝炎/贫血/短期生存Key words
Acute-on-chronic liver failure/Anemia/Hepatitis B/Short-term survival引用本文复制引用
季淑静,王梦洁,陈金军..慢加急性乙型肝炎肝衰竭患者贫血特点分析[J].实用肝脏病杂志,2016,(1):55-59,5.基金项目
国家自然科学基金资助项目（81270533、81470038）；“863”计划项目（2012AA022605）；教育部博士点专项课题 （）
