实用肝脏病杂志Issue(1)：121-124,4.DOI:10.3969/j.issn.1672-5069.2016.01.035
肝纤维化发生机制研究新进展
Progress in the pathogenesis of liver fibrosis
摘要
Abstract
Liver fibrosis is a pathological process characterized by intrahepatic diffuse excess deposition of extracellular matrix (ECM),which is also a common response occurred in the progression of varied chronic liver disease to cirrhosis. As ECM is mainly secreted by hepatic stellate cells (HSC) and its activation process is the central part of liver fibrosis development. In this review,we will summarize the mechanism of HSC activation in combination with the roles of hepatocytes,other non-parenchymal cells and various profibrogenic cytokines. This paper will also describe the significance of intestinal flora alteration and aberrant expression of microRNAs in the development of liver fibrosis.关键词
肝纤维化/发生机制/细胞外基质/肠道菌群失调/微小RNAKey words
Liver fibrosis/Pathogenesis/Hepatic stellate cell/Extracel ular matrix/Intestinal flora alteration/MicroRNAs引用本文复制引用
陈宵瑜(综述),杨长青(审校)..肝纤维化发生机制研究新进展[J].实用肝脏病杂志,2016,(1):121-124,4.基金项目
国家自然科学基金资助项目（No.81370559）；上海市科技创新行动计划项目（12431901002）；上海市重要疾病联合攻关重大项目（2014ZYJB0201）；上海市新兴前沿技术联合攻关项目 （）
