天津中医药Issue(12)：739-742,4.DOI:10.11656/j.issn.1672-1519.2015.12.10
调肝导浊方对apoE-/-小鼠血脂及主动脉斑块面积的影响
Effects of Tiaogan Daozhuo prescription on blood lipid and aorta plaque area in apoE-/- mice
摘要
Abstract
Objective] To observe the effect of Tiaogan Daozhuo prescription on the blood lipid and aortic plaque in apoE-/- mice. [Methods] ApoE-/- mice were randomly divided into model group and Tiaogan Daozhuo group, high fat diet for 12 weeks, C57BL/6L mice served as the control group were fed with normal diet, after 12 weeks, detection of serum TC, TG, HDL-C and LDL-C level, oil red O staining assessment aorta plaque scope; small animal ultrasound instrument to detect the aortic plaque area and degree of stenosis. [Results] TC, TG, HDL-C, LDL-C in the model group were higher than that in control group (P﹤0.05 or P﹤0.01). Compared with model group LDL-C decreased in Tiaogan Daozhuo group (P﹤0.05), and there was no significant difference of TC, TG and HDL-C. Oil red O staining showed that the range of plaque in the model group was the first, followed by the Tiaogan Daozhuo group, and the last was the control group. Compared with control group, the plaque area and stenosis of aorta in model group were significantly increased (P﹤0.01), intervention by Tiaogan Daozhuo prescription. The plaque area was decreased (P﹤0.05), and the degree of stenosis was significantly reduced (P﹤0.01). [Conclusion] Tiaogan Daozhuo prescription can decrease the serum levels of LDL-C in apoE-/- mice, and decrease the aortic plaque area and improve the degree of vascular stenosis.关键词
动脉粥样硬化/apoE-/-小鼠/调肝导浊方/血脂/斑块Key words
atherosis/apoE-/- mice/Tiaogan Daozhuo prescription/blood fat/plaque分类
医药卫生引用本文复制引用
索艳荣,曾文赟,王一婧,李虎虎,郭茂娟,范英昌..调肝导浊方对apoE-/-小鼠血脂及主动脉斑块面积的影响[J].天津中医药,2015,(12):739-742,4.基金项目
国家自然科学基金项目（81202797）；天津市自然科学基金项目（08JCYBJC10800）。 （）
