中国临床药理学杂志Issue(24)：2477-2478,2.DOI:10.13699/j.cnki.1001-6821.2015.24.034
葡萄糖醛酸衍生物的合成及结构鉴定
Investigation about the synthesis and structure determination of glycopeptide containing glucuronic acid
曾莉 1张建伟1
作者信息
- 1. 首都医科大学 化学生物学与药学院 化学生物学系，北京 100069
- 折叠
摘要
Abstract
Objective To research tetra -peptide synthesis glucuronic acid and arginine – glycine -asparagine -phenylalanine peptide se-quence were reacted using the standard coupling method dicyclohexylcar-bodiimide and 1-hydroxybenzotriazole in solution.Methods Glucuron-ic acid was reacted with arginine-glycine-asparagine-phenylalanine peptide sequence in tetrahydrofuran to give tetra-peptide.The product obtained was purified by silica gel column chromatography and the struc-ture of product was determined by nuclear magnetic resonance and mass spectroscopy.Results The product was afforded 59 mg in 43%yield using 50 mg tetraacetyl glucuronic acid and the structure of tetra-peptide contai-ning glycosylation was determined.Conclusion The reaction of glucuronic acid with peptide was explored and an effective procedure for the preparation peptide mimetic containing glucuronic acid was established.关键词
葡萄糖醛酸/寡肽/糖基化Key words
glucuronide/oligopeptide/glycosylation分类
医药卫生引用本文复制引用
曾莉,张建伟..葡萄糖醛酸衍生物的合成及结构鉴定[J].中国临床药理学杂志,2015,(24):2477-2478,2.
