中国临床药理学杂志Issue(24)：2483-2485,3.DOI:10.13699/j.cnki.1001-6821.2015.24.036
生理药代动力学模型在预测转运体介导药物相互作用中的应用
Application of physiologically based pharmacokinetic models in the prediction of drug-drug interactions mediated by transporters
摘要
Abstract
Physiologically based pharmacokinetic ( PBPK ) models are built using a mathematic framework which is similar to these classic phar-macokinetic ( PK ) models, and are parameterized based on known physiology knowledge, and comprise many compartments corresponding to different organs and tissues in the body, which are connected by flow rates that parallel the circulating blood system.The values of PBPK models are gradually appreciated in the industry of drug development, especially in the field of drug -drug interaction due to their robust ability to predict drugs’ kinetic process in vivo.Then some basic concepts, advantages over classic models and their applications in drug-drug interaction fields asso-ciated with transporters of PBPK models are reviewed in the next context.关键词
生理药代动力学模型/转运体/药物相互作用/预测Key words
physiologically based pharmacokinetic/transporter/drug-drug interaction/predicition分类
医药卫生引用本文复制引用
陈琳,刘晓培,夏春华,胡锦芳,熊玉卿..生理药代动力学模型在预测转运体介导药物相互作用中的应用[J].中国临床药理学杂志,2015,(24):2483-2485,3.基金项目
国家自然科学基金资助项目（81160411）；江西省自然科学基金资助项目（20151BAB205084）；江西省青年科学家培养计划资助项目 （）
