中国药理学通报Issue(1)：14-18,5.DOI:10.3969/j.issn.1001-1978.2016.01.004
非编码 RNA 在血管损伤、重塑和老化中的作用
Role of noncoding RNA in vascular injury, remodeling and aging
摘要
Abstract
Non-coding RNAs ( ncRNA ), including ribosomal RNA( rRNA), transfer RNA( tRNA), MicroRNA ( miRNA), long noncoding RNA(lncRNA) and small nucleolar RNA(snoR-NA), are a class of RNA that have multiple functions and are not translated to proteins. MicroRNA and lncRNA are involved in the injury, remodeling and aging of blood vessels, and it is necessary to understand the regulatory roles of MicroRNA and lncRNA in these processes. It is reported that MicroRNA and lncRNA are not only participated in the regulation of oxidative response, inflammation, cell proliferation and migration, and phenotype transition, they are also involved in the regulation of gene expression by conducting different mechanisms, including transcriptional regulation, post-transcriptional modification and chromatin remodeling. These aspects of regulation by MicroRNA and lncRNA are related to cardiovascular diseases, such as ath-erosclerosis, hypertension, myocardial infarction, stroke, pul-monary hypertension and diabetes, and thus provide a new way for genetic diagnosis and therapy of cardiovascular diseases.关键词
MicroRNA/lncRNA/血管损伤/血管重塑/血管老化/血管系统疾病Key words
MicroRNA/lncRNA/vascular injury/vascular re-modeling/vascular aging/diseases of vascular system分类
医药卫生引用本文复制引用
马婧,凌霜,党延启,倪荣镇,郭慧宁,李玉凤,王淑荣,许锦文..非编码 RNA 在血管损伤、重塑和老化中的作用[J].中国药理学通报,2016,(1):14-18,5.基金项目
国家自然科学基金资助项目(No 81274130) （No 81274130）
上海市教委085项目高等教育内涵建设基金(No 085ZY1202) （No 085ZY1202）
