中国药理学通报Issue(1)：19-21,22,4.DOI:10.3969/j.issn.1001-1978.2016.01.005
莪术提取物调控支架后再狭窄血管平滑肌细胞增殖的研究进展
Research progress on curcuma zedoary extracts inhibiting vascular smooth muscle cell proliferation in pathological process of in-stent restenosis
摘要
Abstract
Vascular smooth muscle cells (VSMCs) proliferation is the critical pathological process of in-stent restenosis (ISR). Recent researches indicate that the traditional Chinese medicine curcuma zedoary (E’zhu) can inhibit VSMCs proliferation, with a potential value in preventing and treating ISR. The major ac-tive components of curcuma zedoary are curcuma and β-elemene. The underlying mechanisms involve the inhibition of hemeoxygen-ase-1 expression, blockade of extracellular signal-regulated ki-nase – MAPK and Akt pathways, and subsequent cell cycle ar-rest. This article reviews the recent progress on curcuma zedoary extracts regulating VSMCs proliferation in ISR.关键词
支架后再狭窄/血管平滑肌细胞/莪术/增殖/分子机制/姜黄素Key words
in-stent restenosis/vascular smooth muscle cell/curcuma zedoary/proliferation/molecular mechanisms/curcu-min分类
医药卫生引用本文复制引用
冒慧敏,刘剑刚,赵福海,史大卓,刘秀华..莪术提取物调控支架后再狭窄血管平滑肌细胞增殖的研究进展[J].中国药理学通报,2016,(1):19-21,22,4.基金项目
国家自然科学基金项目(No 81473530) （No 81473530）
国家卫生基金课题项目(No CMH200701110) （No CMH200701110）
中国中医科学院自主课题项目(No ZZ0708106) （No ZZ0708106）
