中国药理学通报Issue(1)：22-26,5.DOI:10.3969/j.issn.1001-1978.2016.01.006
DJ-1蛋白对线粒体的功能调节在帕金森病中的作用
DJ-1 regulates the function of mitochondria in Parkinson’s disease
摘要
Abstract
Mitochondrial dysfunction plays an important role in the process of PD, DJ-1 participates in regulating the function of mitochondria,which has an effect on the protection of mitochon-dria. DJ-1 mutations can lead to the decrease of the activity of mitochondrial complex Ⅰ, the decrease of mitochondrial mem-brane potential and then mitochondrial fragmention and mitoph-agy, and then further damage neurons and trigger PD. This re-view presents the role of DJ-1 in regulating the function of the mitochondria in the pathogenesis of Parkinson's disease(PD).关键词
DJ-1/线粒体/帕金森病/线粒体复合物 I/线粒体自噬/氧化应激/线粒体稳态Key words
DJ-1/mitochondria/Parkinson’ s disease/mito-chondrial complex I/mitophagy/oxidative stress/mitochondrial homeostasis分类
医药卫生引用本文复制引用
郭涌斐,孙懿,赵欣,蒲小平..DJ-1蛋白对线粒体的功能调节在帕金森病中的作用[J].中国药理学通报,2016,(1):22-26,5.基金项目
国家重大科学仪器设备开发专项资助项目( No 2013YQ 030651) （ No 2013YQ 030651）
国家重大新药创制重大专项资助项目( No 2012ZX09103201-042) （ No 2012ZX09103201-042）
国家自然科学青年基金项目( No 81202937) （ No 81202937）
