中国医学创新Issue(33)：42-45,46,5.DOI:10.3969/j.issn.1674-4985.2015.33.014
联合应用促性腺激素释放激素激动剂和孕三烯酮治疗子宫内膜异位症患者的预后分析
Prognosis Analysis of Gonadotropin-releasing Hormone Agonist Combined with Gestrinone after Laparoscopic Surgery Treatment for the Patients with Endometriosis
摘要
Abstract
Objective:To discuss the clinical effect of Gonadotropin-releasing hormone agonist (GnRH-a) combined with Gestrinone after laparoscopic surgery patients with endometriosis, and analyze the influences of the ovarian function, recurrence and pregnancy again.Method: 164 patients with endometriosis who accepted the treatment of laparoscopic surgery in our hospital were selected from January 2012 to March 2014,they were randomly divided into four groups, combinational group of 38 cases (it was treated by GnRH-a combined with Gestrinone after laparoscopic surgery),GnRH-a group of 43 cases (it was only treated by GnRH-a therapy),gestrinone group of 47 cases (it was only treated by Gestrinone), the control group of 36 cases (it was only treated by placebo).The remission rate, sex hormone levels, recurrence rate, and pregnancy rate of four groups were compared.Result:Compared the remission rate of the combinational group, GnRH-a group and Gestrinone group, the differences were not statistically significant (P>0.05);but the remission rate of three groups were significantly higher than that of control group, the differences were statistically significant(P<0.05).After treatment, the serum levels of E2,LH and FSH of combinational group, GnRH-a group and Gestrinone group were significantly decreased than before treatment, the differences were statistically significant(P<0.05).Compared the change of serum levels of E2,LH and FSH in combinational group and GnRH-a group, the differences were not statistically significant(P<0.05);but the change of serum levels of E2,LH and FSH in the two groups were significantly lower than that of Gestrinone group, the differences were statistically significant (P<0.05).Compared the recurrence rate of combinational group, GnRH-a group and Gestrinone group, the differences were not statistically significant (P>0.05);but the recurrence rate of three groups were significantly lower than that of control group, the differences were statistically significant(P<0.05). The pregnancy rate and good rate of pregnancy outcome of combinational group, GnRH-a group and Gestrinone group were significantly better that of control group, the differences were statistically significant(P<0.05);there was not significant difference of those between combinational group and GnRH-a group(P>0.05),but they were significantly better than those of Gestrinone group, the differences were statistically significant(P<0.05).Conclusion: After laparoscopic surgery, the clinical efficacy and the prevention recurrence of GnRH-a combined with Gestrinone,only GnRH-a and only Gestrinone are equivalent,the effect of improving ovarian function and promoting good pregnancy outcomes of GnRH-a combined with Gestrinone are similar with GnRH-a, but better than only Gestrinone.关键词
子宫内膜异位症/促性腺激素释放激素激动剂/孕三烯酮/卵巢功能/妊娠结局Key words
Endometriosis/Gonadotropin-releasing hormone agonists/Gestrinone/Ovarian function/Pregnancy outcomes引用本文复制引用
闵丽..联合应用促性腺激素释放激素激动剂和孕三烯酮治疗子宫内膜异位症患者的预后分析[J].中国医学创新,2015,(33):42-45,46,5.基金项目
江西省卫生厅科技计划基金课题 （）
