摘要
Abstract
Objective:To investigate the effect of laparoscopic radical gastrectomy on inflammatory reaction and immune function.Method:30 patients who were treated with laparoscopic radical gastrectomy in our hospital from January 2014 to January 2015 were selected as the laparoscopic group.30 patients who were treated with open radical gastrectomy were selected as the control group at the same time.The changes of CD4+/CD8+,CD8+,CD4+,TNF-α and IL-6 in the two groups were compared before and after operation.Result:Before operation,the differences in levels of TNF-α and IL-6 were not statistically significant(P>0.05).The second days after operation,the levels of TNF-α and IL-6 in the two groups were all higher than those before operation,the levels of TNF-α and IL-6 in the control group were higher than those in the observation group,the differences were statistically significant(P<0.05).The first day after operation,the levels of CD4+/CD8+ and CD4+ in the two groups were all lower than those before operation,the differences were statistically significant(P<0.05),but the differences between the two groups were not statistically significant(P>0.05). The first and seventh day after operation,the differences in the levels of CD8+ between the two groups were not statistically significant(P>0.05).The seventh day after operation,the levels of CD4+ and CD4+/CD8+ in the control group were lower than those before operation and the first day after operation,they were also lower than those in the observation group,the differences were all statistically significant(P<0.05).But the differences in levels of CD4+ and CD4+/CD8+ that before operation and that the seventh day after operation were not statistically significant(P>0.05).Conclusion:Laparoscopic gastric carcinoma has the advantages of small trauma,small effect on the whole body inflammatory reaction and immune function.It can protect the immune function of patients better than open operation.关键词
腹腔镜胃癌根治术/炎症因子/免疫功能Key words
Laparoscopic radical gastrectomy/Inflammatory factor/Immune function
