肿瘤药学Issue(6)：444-448,5.DOI:10.3969/j.issn.2095-1264.2015.06.010
盐酸羟考酮控释片与芬太尼透皮贴剂治疗中-重度癌痛的疗效及不良反应观察
Observation of Curative Effects and Adverse Effects of Oxycodone Hydrochloride Controlled-release Tablets and Fentanyl Transdermal Patches on the treatment of Moderate or Severe Cancer Pain
苏婧 1朱跃红 1吴尉 1罗以1
作者信息
- 1. 中南大学湘雅医学院附属肿瘤医院肿瘤内科，湖南长沙，410013
- 折叠
摘要
Abstract
Objective To compare the curative effects and adverse effects of oxycodone hydrochloride controlled-release tablets and fentanyl transdermal patches in the treatment of moderate or severe cancer pain. Methods The selected 80 pa-tients with moderate or severe cancer pain were randomly divided into two groups. The 42 patients in oxycodone hydrochlo-ride controlled-release tablets group take Oxycontin orally. The initial dosage for initially treated patients was 10mg/12h, while the patients who previously had morphine were given oxycodone hydrochloride controlled-release tablets according to the used dosage. The 38 patients in fentanyl transdermal patches group were treated with Durogesic for external use. The initial dosage for initially treated patients was 25μg·h-1, replaced after 72h. For patients treated with morphine previously, the dosage of Durogesic=daily morphine dose×0.5. Doses should be adjusted until pain relief reach to NRS 0-3. The curative effects, quality of life and adverse effects were compared between the two groups. Results The total alleviating rate of pa-tients was 90.48%in the oxycodone hydrochloride controlled-release tablets group, and 92.11%in the fentanyl transdermal patches group. There was no statistical difference between the two groups (P>0.05). NRS were significantly reduced after treatment in both groups, and differences in each group were statistical between before and after the treatment (P<0.01), but had no statistical significance between the two groups (P>0.05). KPS were significantly improved after treatment in both groups. There were statistical differences in each group before and after the treatment (P<0.01), but no statistical difference between the two groups (P>0.05). The incidence rate of nausea and constipation was higher in oxycodone hydrochloride controlled-release tablets group (P<0.05). There were no statistical differences in the incidence rate of dizziness, lethargy and dysuresia between the two groups (P>0.05). Conclusion Both oxycodone hydrochloride controlled-release tablets and fentanyl transdermal patches are effective for moderate or severe cancer pain, and can improve the quality of life. Fentanyl transdermal patches result in lower incidence of gastrointestinal reaction.关键词
盐酸羟考酮控释片/芬太尼透皮贴剂/癌痛/疗效/不良反应Key words
Oxycodone hydrochloride controlled-release tablets/Fentanyl transder-mal patches/Cancer pain/Cura-tive effect/Adverse effect分类
医药卫生引用本文复制引用
苏婧,朱跃红,吴尉,罗以..盐酸羟考酮控释片与芬太尼透皮贴剂治疗中-重度癌痛的疗效及不良反应观察[J].肿瘤药学,2015,(6):444-448,5.
