摘要
Abstract
Objective To investigate the expressions and clinical significances of p53, ki-67 and cd34 in the cervical lesions. Methods Immunohistochemica1 method was used to detect the expressions of P53, Ki-67 and CD34 in the normal uterine cervix, cervical intraepithelial neoplasia(CIN) and cervical infiltrating carcinoma. Results In normal uterine cervix, CIN and cervical in-filtrating carcinoma, the positive expression rates of P53 were respectively 0%(0/28), 39.58%(19/48) and 69.44%(25/36), and the positive expression rates of Ki-67 were respectively 3.57%(1/28), 52.08%(25/48) and 86.11%(31/36). The microvessel density (MVD) of marked CD34 was respectively (12.46±4.63)/HP, (30.12±7.46)/HP and (42.12±5.48)/HP in the above mentioned tissues. The pair-wise comparison showed that the positive expression rates of P53, Ki-67 and CD34 had statistical difference in the CIN I-II, CIN III and cervical infiltrating carcinoma tissues(P<0.05). Conclusion The expressions of P53, Ki-67 and CD34 increased with the progression of the cervical lesions. The expression of P53 and Ki-67 had no correlation with the differentiation degree of infiltrat-ing carcinoma, while the expression of CD34 was positively correlated with the differentiation degree of cervical infiltrating carci-noma. Combined detection of P53, Ki-67 and CD34 can be helpful for the early diagnosis and classification of CIN.关键词
宫颈病变/P53/Ki-67/CD34/微血管密度Key words
Cervical lesion/P53/Ki-67/CD34/MVD分类
医药卫生
