广东医学2015，Vol.36Issue(24)：3772-3775,4.
不同透析方式及透析龄对终末期肾病患者微炎症状态的影响及临床意义
Effects of different dialysis approaches and duration on microinflammation in end-stage renal disease patients
摘要
Abstract
Objective To investigate effects of different dialysis approaches and duration on microinflammation in end-stage renal disease patients and its association with patients′nutritional status , anemia and heart function .Methods 45 hemodialysis (HD) patients, 38 peritoneal dialysis (PD) patients and 25 non-dialysis patients with end -stage renal disease and 30 healthy volunteers were enrolled in the study .Hemodialysis and peritoneal dialysis patients were di-vided into two subgroups (Group 1, duration of dialysis <2 years and Group 2, duration>2 years) .Fasting venous blood were collected to detect C -reactive protein (CRP), serum creatinine (Scr), blood urea nitrogen (BUN), albumin (ALB), hemoglobin (Hb), serum ferritin (SF), lipoprotein a (LP (a)), B-type natriuretic peptide (BNP), etc. Left ventricular ejection fraction ( LVEF) was measured by echocardiography .Results (1) In patients with end -stage renal disease (including the HD group, PD group, and the non -dialysis group), CRP levels were significantly higher than that in the control group , with levels in the HD group and PD group higher than that in the non -dialysis group ( P<0.05).(2) CRP level in the PD group was lower than in the HD group (P<0.05).CRP level in the HD1 group (dura-tion of dialysis <2 years) was lower than that in the HD2 group (duration of dialysis>2 years) (P<0.05).CRP level in the PD1 group (duration of dialysis <2 years) was similar to that in the PD2 group (duration of dialysis >2 years) (P>0.05).(3) In patients with end-stage renal disease (including the HD, PD and non-dialysis groups), CRP lev-els were not correlated with Scr, SF levels (P>0.05), but negatively correlated with Hb, ALB, LP (a) (P<0.05). (4) In end-stage renal disease patients with concurring heart failure (including HD group, PD group and the non-dial-ysis group), CRP levels were elevated with deteriorating heart function (P<0.05).In ESRD patients with heart failure CRP levels were negatively correlated with LVEF ( P<0.05 ) , and positively correlated with plasma BNP ( P<0.05 ) . Conclusion Microinflammatory state is common in ESRD patients .And imcroinflammatory state is closely related to heart failure, malnutrition, anemia, etc.Microinflammation in HD patients are more severe than patients on PD , which aggravates with increasing duration of dialysis .关键词
终末期肾病/血液透析/腹膜透析/微炎症状态Key words
ESRD/hemodialysis/peritoneal dialysis/microinflammation引用本文复制引用
李拱榆,唐小玲,曲廖准..不同透析方式及透析龄对终末期肾病患者微炎症状态的影响及临床意义[J].广东医学,2015,36(24):3772-3775,4.基金项目
广东省汕头市重点科技项目(编号:汕府科[2011]46-15) （编号:汕府科[2011]46-15）
