林产化学与工业2015，Vol.35Issue(6)：69-77,9.DOI:10.3969/j.issn.0253-2417.2015.06.012
樟脑酸基硫脲类化合物的合成及抑菌活性研究
Synthesis and Antifungal Activity of Camphoric Acid-based Thiourea Derivatives
摘要
Abstract
Ten novel camphoric acid-based thiourea compounds (5a 5j) were prepared using camphoric acid and aminoethyl substituted phenyl thioureas as starting materials. The target compounds were characterized by FT-IR,1H NMR,13 C NMR,LC-MS,and elemental analysis. The antifungal activities of the compounds 5a 5j were tested. The preliminary bioassay showed that most of the target compounds exhibited certain antifungal activities,in which camphoric acid-based (o-methoxy)phenyl thiourea 5c (R=o-CH3O) and camphoric acid-based (m-methoxy)phenyl thiourea 5d (R=m-CH3O) had inhibition rate of 86. 9 % against Alternaria solani,and camphoric acid-based (m-methoxy)phenyl thiourea 5d,camphoric acid-based (m-methyl)phenyl thiourea 5g (R=m-CH3) and camphoric acid-based (p-bromo)phenyl thiourea 4i ( R=p-Br) had inhibition rate of 86. 1% against Physalospora piricola at the concentration of 50 mg/L. In addition,compound 5i also had the best inhibitory activity against cercospora arachidicola(73. 6%).关键词
樟脑酸/硫脲/合成/抑菌活性Key words
camphoric acid/thiourea/synthesis/antifungal activity分类
化学化工引用本文复制引用
马献力,刘陆智,段文贵,石贤春,李芳耀,华忠泽..樟脑酸基硫脲类化合物的合成及抑菌活性研究[J].林产化学与工业,2015,35(6):69-77,9.基金项目
国家自然科学基金资助项目(31260164) （31260164）
广西高校科学技术研究重点项目(ZD2014098) （ZD2014098）
