山东中医杂志2016，Vol.35Issue(1)：61-63,3.
扶正法、祛邪法对Lewis肺癌小鼠的抑瘤作用及机制研究
Study of the Anti-tumor Effect and Mechanism of Strengthening Healthy Qi and Eliminating Pathogenic Factors on Mice Model with Lewis Lung Cancer
摘要
Abstract
Objective:To study of the anti-tumor effect and mechanism of strengthening healthy Qi and elimi-nating pathogenic factors on mice model with Lewis lung cancer. Method:The Lewis lung cancer mouse model was established,the mic were divided into different groups and given intervention. The anti-tumor rate of each group was calculated,the expression of BCL-2 in tumor cells was measured with immunohistochem-istry,the expressions of caspase-3 mRNA,surviving mRNA were detected with real-time PCR. Results:Qizhen guben formula and Qinlian zhengji formula all had certain anti-tumor effect,with the anti-rate 18.42% and 29.24% respectively,and there were no significant differences between two groups(P>0.05). When compared to the control group,they all could significantly promote the expression of caspase mRNA and down-regulate the expression of BCL-2 survivin mRNA,but the their effect was not better than cisplatin. Conclusion:Qizhen guben formula and Qinlian zhengji formula did possess anti-tumor effect and this effect of Qinlian Zhengji formual was stronger. Their mechanism of action may be related to promoting the expression of caspase mR-NA and down-regulating the expression of BCL-2 and survivin mRNA.关键词
扶正法/祛邪法/肺癌/机制/小鼠Key words
strengthening healthy Qi/eliminating pathogenic factors/lung cancer/mechanism/mice分类
医药卫生引用本文复制引用
齐元富,张盈盈,李慧杰,郑祎,刘寨东..扶正法、祛邪法对Lewis肺癌小鼠的抑瘤作用及机制研究[J].山东中医杂志,2016,35(1):61-63,3.基金项目
山东省中医药科技发展计划(编号:2009Z003) （编号:2009Z003）
