中国药房2016，Vol.27Issue(1)：67-69,3.DOI:10.6039/j.issn.1001-0408.2016.01.22
丹参片和丹参注射液对多柔比星在大鼠体内药动学的影响
Effects of Danshen Tablets and Danshen Injection on the Pharmacokinetics of Doxorubicin in Rats in vivo
李光慧 1戴维 2李芳萍 1张晓丹 1袁媛 1赵永红 1季瑛 1梁建英2
作者信息
- 1. 上海市静安区中心医院/复旦大学附属华山医院静安分院,上海 200040
- 2. 复旦大学药学院药物分析教研室,上海 200032
- 折叠
摘要
Abstract
OBJECTIVE:To study the effects of Danshen tablets or Danshen injection combination on the pharmacokinetics of doxorubicin in rats in vivo. METHODS:18 SD rats were randomly divided into group A,B and C. Group A was given doxorubicin 8 mg/kg intravenously via left jugular trunk;group B was given Danshen injection 0.5 ml intravenously via left jugular trunk,and 0.5 h later given doxorubicin 8 mg/kg intravenously via left jugular trunk;group C was given Danshen suspension 1 ml(18 tablets dissolved in 50 ml pure water)intragastrically,and 7 d later given doxorubicin 8 mg/kg intravenously via left jugular trunk. 0.6 ml venous blood were extracted from the right jugular vein 0,0.083,0.25,0.5,0.75,1,2,4,6,8,12 and 24 hours after medica-tion. The plasma concentration of doxorubicin was determined by HPLC;the pharmacokinetic parameters were calculated by using 3p97 software;the difference of pharmacokinetic parameters were compared among 3 groups. RESULTS:Compared with group A, CL and Vs of group B increased while AUC0-t decreased(P<0.05);Vs of group C decreased(P<0.05),k10 increased and t1/2β de-creased. CONCLUSIONS:Danshen tablet/Danshen injection can increase the distribution speed of doxorubicin into tissues,and both can improve the concentration of drug in tumor focus.关键词
多柔比星/丹参片/丹参注射液/药动学/高效液相色谱法/大鼠Key words
Doxorubicin/Danshen tablets/Danshen injection/Pharmacokinetics/HPLC/Rat分类
医药卫生引用本文复制引用
李光慧,戴维,李芳萍,张晓丹,袁媛,赵永红,季瑛,梁建英..丹参片和丹参注射液对多柔比星在大鼠体内药动学的影响[J].中国药房,2016,27(1):67-69,3.
