中国药房2016，Vol.27Issue(1)：89-91,3.DOI:10.6039/j.issn.1001-0408.2016.01.29
混合均匀设计法优化白芍提取工艺
Optimization of the Extraction Technology of Paeonia lactiflora by Mixed Uniform Design
尹雪 1孙萍 2温学森 3姜国萍1
作者信息
- 1. 山东中医药大学药学院,济南 250355
- 2. 山东中医药大学附属医院,济南 250011
- 3. 山东大学药学院,济南 250012
- 折叠
摘要
Abstract
OBJECTIVE:To optimize the extraction technology of Paeonia lactiflora. METHODS:The surface figure made by mixed uniform design combined with the quadratic polynomial stepwise regression equation is adopted to optimize the extraction technology of P. lactiflora by using the content of paeoniflorin as index,with extraction solvent,the amount of extraction solvent, extraction time,extraction times as factors. RESULTS:The optimal extraction technology of P. lactiflora was as follows as 90%ethanol,12-folds extraction solvent,extracting for 150 min,extracting for 2 times. The measured value of 3 validation tests were 2.848 4%,2.795 7%,2.841 9%(RSD=0.82%,n=3),which was close to the predicted value 2.848 4%. CONCLUSIONS:The method is convenient and accurate,and can be used for the extraction of P. lactiflora.关键词
白芍/芍药苷/混合均匀设计/曲面图/提取工艺Key words
Paeonia lactiflora/Paeoniflorin/Mixed uniform design/Surface figure/Extraction technology分类
医药卫生引用本文复制引用
尹雪,孙萍,温学森,姜国萍..混合均匀设计法优化白芍提取工艺[J].中国药房,2016,27(1):89-91,3.
