中国药房2016，Vol.27Issue(1)：98-100,3.DOI:10.6039/j.issn.1001-0408.2016.01.32
星点设计-响应面法优化盐酸氮斯汀温敏型原位凝胶滴鼻剂处方
Optimization of the Formulation of Azelastine Hydrochloride Thermosensitive In-situ Gel Nasal Drops by Central Composite Design-Response Surface Methodology
王宏丽 1别海燕 1司传平 2王英婷1
作者信息
- 1. 济宁市第一人民医院,山东济宁 272100
- 2. 济宁医学院,山东济宁272000
- 折叠
摘要
Abstract
OBJECTIVE:To optimize Azelastine hydrochloride (AH) thermosensitive in-situ gel nasal drops formulation. METHODS:Using poloxamer 407(P407)and poloxamer 188(P188)as excipients,AH thermosensitive in-situ gel was prepared by cold solution method. The formulation was optimized by central composite design-response surface methodology using the amount of P407 and P188(g/100 ml)as factors and phase-transition temperature as index. Binomial expression was fitted,and pre-dicted and measured values were compared. RESULTS:The correlation coefficient R2 fitted by binomial expression was equal to 0.986 5. The optimal formulation was as follows as P407 for 20.414 4%,P188 for 5.035 4%,measured value of(30.81±0.02)℃, predicted values of 31 ℃,deviation of 0.61%. CONCLUSIONS:AH thermosensitive in-situ gel nasal drops formulation is opti-mized by central composite design-response surface methodology.关键词
盐酸氮斯汀/温敏型原位凝胶/滴鼻剂/星点设计-响应面法Key words
Azelastine hydrochloride/Thermosensitive in-situ gel/Nasal drops/Central composite design-response surface methodology分类
医药卫生引用本文复制引用
王宏丽,别海燕,司传平,王英婷..星点设计-响应面法优化盐酸氮斯汀温敏型原位凝胶滴鼻剂处方[J].中国药房,2016,27(1):98-100,3.
