中国药业2015，Vol.24Issue(23)：31-32,2.
维格列汀联合二甲双胍对2型糖尿病的疗效及慢性炎症状态的影响
Vildagliptin Combined with Metformin in Treating Type 2 Diabetes and Its Influence on Chronic Inflammation State
柳湘洁 1陈佳 1姚弘毅 1丁吟2
作者信息
- 1. 华中科技大学同济医学院附属梨园医院,湖北 武汉 430077
- 2. 贵州电力职工医院,贵州 贵阳 550002
- 折叠
摘要
Abstract
Objective To explore the efficacy of vildagliptin in treating patients with type 2 diabetes and its influence on chronic in-flammatory state. Methods 130 patients with type 2 diabetes from July 2013 to September 2014 were randomly divided into obser-vation group and control group. The control group received metformin treatment, the observation group was added with vildagliptin. The two groups were both treated of 10 weeks. Results After treatment, the total effective rate of the observation group was 96. 92%, which was obviously higher than 86. 15% of the control group ( P < 0. 05 );compared with before treatment, the CRP, IL-6 and TNF-αexpression levels of the two groups were significantly decreased ( P < 0. 05 ) , and the decrease in the observation group was more obvious ( P < 0. 05 );the incidence rate of abdominal discomfort in the observation group was higher than the control group ( P < 0. 05 ) , which the incidence rate of nausea and hypoglycemia was similar to the control group ( P > 0. 05 ) . Conclusion Vildagliptin combined with metformin in treating patients with type 2 diabetes can effectively control blood sugar, reduce the inflammatory response, improve the in-sulin resistance, with less severe adverse reactions.关键词
维格列汀/二甲双胍/2型糖尿病/胰岛素抵抗/慢性炎症Key words
vildagliptin/metformin/type 2 diabetes/insulin resistance/chronic inflammation分类
医药卫生引用本文复制引用
柳湘洁,陈佳,姚弘毅,丁吟..维格列汀联合二甲双胍对2型糖尿病的疗效及慢性炎症状态的影响[J].中国药业,2015,24(23):31-32,2.
