摘要
Abstract
Objective To study the related factors, efficacy and drug resistance of EP and 5-FU+KSM regimen in the treatment of high risk gestational trophoblastic tumor. Methods 76 cases of gestational trophoblastic tumor of high risk pregnancy were divided into 40 cases of EP group and 36 cases of 5-FU+KSM group. Results The efficiency, nausea and vomiting, leukopenia occurred in the two groups had no statistically significant difference ( P > 0. 05 ) . The oral ulcers, diarrhea, time of hospitalization, time of chemotherapy and daily time of chemotherapy in the EP group were significantly less than the 5-FU+KSM group ( P < 0. 05 ) . Those whose previous pregnancy to full-term pregnancy, from the last time more than 12 months, the prognosis of FIGO were more than or equal to 13 points, tumor diameter greater than or equal to 5 mm resistance rate were significantly higher than those whose previous pregnancy was less than a month, from the last 12 months of pregnancy, the prognosis total score of FIGO 'total score of 7 to 12, diameter of the tu-mors' 5mm ( P < 0. 05 ) . Conclusion The EP regimen used for the treatment of high risk pregnancy trophoblastic tumor is better than that of 5-FU+KSM. And the previous pregnancy to full-term pregnancy, from the last time more than 12 months, the prognosis of FIGO total score more than 13 points, the tumor diameter greater than or equal to 5mm are likely to be associated with drug resistance factors of GTN.关键词
足叶乙苷/顺铂/5-氟尿嘧啶/更生霉素/高危妊娠滋养细胞肿瘤/耐药Key words
cisplatin/EP/5-FU/KSM/high risk gestational trophoblastic tumor/drug resistance分类
医药卫生
