摘要
Abstract
Objective To investigate the clinical efficacy and safety of small dose of spironolactone in treating coronary heart disease and chronic heart failure. Methods 124 cases of patients with chronic heart failure were divided into the study group and control group according to the random number table method. The control group was treated with routine treatment, while the study group was treated with small dose of spironolactone on the basis of conventional treatment. Results The 6 min walking distance after 3 months and 6 months treatment of the two groups were significantly higher than before treatment ( t=3. 21, 3. 02, 5. 44, 3. 85, P < 0. 05 );the 6 min walking distance after 6 months treatment in the study group was significantly longer than that in the control group ( t=3. 52, P < 0. 05 );HR, blood pressure and heart function classification after 3, 6 months treatment of the two groups were improved significantly than those before treatment, but the study group improved more significantly than the control group ( t=3. 01, 352, 288, 290, 278, 2. 86, 3. 62, 355, P < 0. 05 );the main indexes of ultrasound echocardiography diagram in the two groups after 3, 6 months treatment were improved sig-nificantly than those before treatment, but the study group improved more significantly than the control group ( t=2. 88, 3. 02, 2. 92, 2. 91, 2. 85, 3. 22, 3. 11, 3. 28, P < 0. 05 ) . The total effective rate of clinical treatment in the study group ( 91. 94% ) was significantly higher than that of control group ( 75. 81% ) , and the difference was statistically significant (χ2=5. 96, P < 0. 05 ) . There was no signifi-cant difference in the incidence rate of adverse reactions between the two groups (χ2=0. 21, P > 0. 05 ) . Conclusion Conventional anti heart failure therapy combined with small dose of spironolactone can effectively reduce cardiac preload. It can effectively prevent coro-nary heart disease complicated with heart failure patients with myocardial fibrosis and left ventricular remodeling. It can improve cardiac function, and increase exercise tolerance, which is worthy of clinical promotion.关键词
螺内酯/冠心病/慢性心力衰竭Key words
spironolactone/coronary heart disease/chronic heart failure分类
医药卫生
